Table 2. UUI and MIA of Compounds 1 and 2 in Scheme 1.

		UUIa
Compound	R1	IC50 (μM)	%	MIAb IC50 (μM) or %	LogPc
1		10.8	52.1	3.6	3.89
2a	H	2.5	67.5	43%	2.70
2b	OMe	>100	21.7	–10%	2.57
2c	I	5.3	65.1	53 μM	4.05
2d	CN	83.9	26.3	47%	2.73
2e	SMe	>100	24.2	40 μM	3.14
2f	tert-Butyl	31.6	32.4	6.6 μM	4.4
2g	Cyclopropyl	8.8	67.8	24 μM	3.43
2h	Cl	14.7	38.2	31 μM	3.26
2i	CF3	>100	30.0	40%	3.62

^aUUI: Inhibitory activity of urate uptake into RPTECs, IC₅₀ and % inhibition at 10 μM.

^bMIA values are defined in Table 1.

^cLogP was calculated using ChemBioDraw UltraVer.14.