Table 7. Properties of 11 and BBR.

Rat	Cmax or C0a (ng/mL)	AUC0-infb (ng·h/mL)	BA.c
11	1085.8 ± 100.4	5744.7 ± 188.8	86.8%
0.3 mg/kg p.o.
11	2401.3 ± 65.6	6619.5 ± 2041.8
0.3 mg/kg i.v.

Cebus monkeys	AUC0–24ha (μg·h/mL)	FEUAd (%)	Difference of ΔPUAefrom control (mg/dL)
11	108.55 ± 52.94	16.5 ± 4.2	0.97
5 mg/kg p.o.
BBR	95.24 ± 28.12	11.5 ± 7.9	0.46
30 mg/kg p.o.

In vitro evaluation	URAT1 inhibition IC50 (nM)
11	37.2
BBR	190

^aMaximum concentration (C_max or C₀).

^bArea under the blood concentration–time curve (AUC); inf: infinity.

^cBA.:Bioavailability.

^dFE_UA: Fractional excretion of urate at 0–4 h; FE_UA value of control: 8.9 ± 4.0%.

^eΔP_UA: Changes in plasma urate level at 0–8 h; value of control: 1.65 ± 0.78 mg/dL.