Table 2. Pharmacokinetics of Compound 1 in Mouse, Rat, and Cynomolgus Monkey.

species	mouse		rat		cyno
route	IV	PO	IV	PO	IV	PO
dose (mg/kg)	3	10	3	10	3	10
CL (mL/min/kg)	17.2		9.0		8.4
Vss (L/kg)	0.63		0.30		1.1
T1/2 (hr)	2.1	1.8	2.1	3.2	4.8	2.0
Cmax (mg/mL)	6270	423	9130	588	5100	2820
AUC (ng·hr/mL)	2910	2960	5610	2230	6420	5660
%F		20		12		27