Table 1:
Parameters for costs and disability weights
| Value | Source | |
|---|---|---|
| Costs* | ||
| Standard diagnostic evaluation (passive case finding) | ||
| Clinic visit for initial diagnosis (excluding tests) | $14·36 | Sinanovic et al (2015)24 |
| Xpert MTB/RIF (treatment naive only) | $14·80 | NHLS state price list25 |
| Mycobacterium tuberculosis culture (treatment experienced only) | $7·58 | NHLS state price list25 |
| Drug-susceptibility testing | $14·99 | NHLS state price list25 |
| Smear microscopy | $1·34 | NHLS state price list25 |
| Chest x-ray | $23·84 (16·22–33·85) | Menzies et al (2012)15 |
| Tuberculosis or HIV treatment | ||
| Drug-susceptible tuberculosis, full course | $708·15 (477·30–939·00) | Vassall et al (2011),26 Pooran et al (2013)27 |
| Multidrug-resistant tuberculosis, full course | $5446·85 (3225·68–7669·57) | Vassall et al (2011),26 Pooran et al (2013)27 |
| ART, per month | $151·98 (122·47–184·44) | Menzies et al (2012)15 |
| Post-treatment follow-up examination | ||
| Follow-up clinic visit | $6·46 | Sinanovic et al (2015)24 |
| Mycobacterium tuberculosis culture screening for tuberculosis | $7·58 | NHLS state price list25 |
| Secondary IPT | ||
| IPT including monthly outpatient follow-up, per year | $20·25 (11·97–34·11) | Kim et al (2018),28 Johnson et al (2018)29 |
| Management of drug-induced liver injury, per event | $35·86 (24·22–90·06) | Kim et al (2018)28 |
| 7-day hospitalisation costs per severe drug-induced liver injury event | $813·05 (334·60–886·48) | Kim et al (2018)28 |
| Disability weights | ||
| Latent tuberculosis infection | 0 | ·· |
| Untreated active tuberculosis, HIV negative | 0·333 (0·224–0·454) | GBD 201630 |
| HIV positive, non-immunocompromised | 0·012 (0·006–0·023) | GBD 201630 |
| HIV positive, immunocompromised | 0·428 (0·274–0·582) | GBD 201630 |
| HIV positive, on ART | 0·078 (0·052–0·111) | GBD 201630 |
Data in parentheses are uncertainty intervals. Price estimates for diagnostic tests were obtained from the NHLS price list and do not contain uncertainty intervals. NHLS=National Health Laboratory Service. IPT=isoniazid preventive therapy. ART=antiretroviral treatment. GBD=Global Burden of Disease Study.
*
Published cost estimates were converted into US dollars and inflated to 2018 price levels.