Table 2.
Pathogenetic mechanisms influenced by v-ncRNAs.
| Mechanisms Influenced by v-ncRNAs | Target Genes | v-ncRNAs | Reference |
|---|---|---|---|
| TIA-1 | mivaRNAI-138 (Adenovirus) | [73] | |
| PKR/eIF-2 | VAI-RNA (Adenovirus) | [74] | |
| TGFβ1, SMAD3 | LAT (HSV-1) | [75] | |
| ActD | miR-H3, miR-H4-3p, miR-H4-5p, miR-H24, miR-H19 (HSV-2) | [77] | |
| Cell Survival (Pro-Apoptotic Factors) | CASP3, PUMA, p53 | EBV-miRNAs | [81,82,83] |
| CASP3 | kshv-miR-K12-1, -miR-K12-3, -miR-K12-4-3p (KSHV) | [84] | |
| p21 | kshv-miR-K12-1 (KSHV) | [85] | |
| Mithocondrial Complex -1 | β-2.7 (MCPyV) | [86] | |
| CASP7 | sfRNAs (Zika) | [87] | |
| BclAF1 | cmv-miR-UL112-1 (CMV), ebv-miR-BART-17-5p (EBV), kshv-miR-K5 (KSHV) | [88] | |
| EZH2, DNMT3a, HDAC1 | HIV1-ncRNAs | [45,92] | |
| HSV1-sisRNAs | [93,94] | ||
| CMV-sisRNAs | [95] | ||
| EBV-sisRNA-1 | [97] | ||
| JMJD3, UTX, LANA | PAN-RNA (KSHV) | [100,101] | |
| MAPK | cmv-miR-UL70 (CMV) | [102] | |
| Virus Infection/Replication | IE72 | cmv-miR-UL112 (CMV) | [103] |
| MAPK, TSPYL2, FXYD2, TAOK2, ST7L, TP73 | cmv-miR-UL112 (CMV) | [104,105] | |
| RNF38, NKIRAS2 | ebv-miR-BART8-3p, -miR-BART13 (EBV) | [106,107,108] | |
| MAP3K2 | ebv-miR-BART18-5p (EBV) | [109] | |
| IkB, NFkB | kshv-miR-K1, -miR-K12-1 (KSHV) | [110] | |
| Rbl2 | kshv-miR-K12-4-5p (KSHV) | [111] | |
| PAN-RNA (KSHV) | [54] | ||
| eIF-2 kinase | EBER1, EBER2 (EBV) | [57,113] | |
| Cell Transformation | FOXP1 | ebv-miR-BART11 (EBV) | [114] |
| PTEN | ebv-miR-BART7-3p (EBV) | [115] | |
| RNF38 | ebv-miR-BART8-3p (EBV) | [107] | |
| CASTOR1 | KSHV-miRNAs | [117] |