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. 2020 Jul 13;6(3):29. doi: 10.3390/ncrna6030029

Figure 4.

Figure 4

Roles of miRNA in cell signaling regulating tumorigenesis. Oncogenic miR-370 upregulates GRM4 expression and miR-96 regulates the expression of FOXO, MTSS1, BRMS1L and ZEB1 proteins. Both resulted in the promotion of proliferation and invasion. Tumor suppressive miR-124, miR-125, miR-137, miR-139, miR-145 and miR-671 can suppress oncogenic targets and inhibit cancer progression. miR-124 can bind Slug, STAT3, ZEB2, PDCD6, Beclin-1, FLOT1, IL-11 and ABCC4. miR-125 can interact with HuR, BAP-1, PTEN, Bcl-2 and CDK3. miR-137 targets FSTL1, BMP-7, ERRα, Tac1 and KDM5. miR-139 can binds TOP2a, RAB1A and OIP5. miR-145 directly inhibits MUC1, ANGPT2, c-Myc, Sox-2 and Ago1. miR-671 regulates FOXM1 expression. All, in turn, result in the regulation of cancer progression by suppressing the cancer hallmarks including chemoresistance.