Table 1.

Binding partners of miRNAs in regulating oncogenesis.

Function	miRNA	Target	Effects	Ref.
Tumor suppressive (inhibition)	miR-26a	RNF6	Proliferation	[53]
		CHD1, GREB1 and KPNA2		[54]
		Metadherin	Proliferation and metastasis	[55]
		MCL-1		[56]
		CCNE2	Sensitize to trastuzumab in Her2+ subtype	[57]
		ERBB2	Sensitize to tamoxifen in ER+ subtype	[58]
	miR-193a/b	DDAH1	Angiogenesis	[172]
		PTP1B	Proliferation and survival	[173]
		MORC4		[174]
		WT1	Proliferation and metastasis	[175]
		RAB22A		[176]
		MCL-1	Sensitize to doxorubicin	[177]
		uPA	Proliferation, cell invasion and metastasis	[178]
	miR-216a/b	TLR4	Suppresses stemness and the release of soluble factors associated with cancer-associated fibroblast activation	[194]
		PKCα	Survival and migration	[195]
		PAK2	Proliferation and metastasis	[196]
		SDCBP		[197]
		P2X7R	Proliferation and survival	[198]
		HDAC8	Proliferation and colony formation	[199]
	miR-223	Caprin-1	Proliferation and invasion	[203]
		STIM1		[204]
		HAX-1	Survival and sensitize to doxorubicin and cisplatin	[205]
		STAT5A	Survival and sensitize to paclitaxel	[206]
		EGF	Proliferation and sensitize radiation-treated breast cancer cells to lapatinib	[207]
Oncogenic (promotion)	miR-1246	CCNG2	Proliferation, migration, chemoresistance to docetaxel, epirubicin and gemcitabine	[456]

Abbreviations: Her2: human epidermal growth factor receptor 2; ER: estrogen receptor.