Table 5.

Predicted exposure to amoxicillin following administration of 250 and 500 mg doses according to a twice daily regimen.

Weight band	Cmax (mg/L)	Cmin (mg/L)	AUC (mg·h/L)	T>MIC (h)MIC = 2 mg/L	T>MIC (h)MIC = 4 mg/L	T>MIC (h)MIC = 8 mg/L
< 4 kg	26 (11 – 120)	14 (6 – 80)	254 (93 – 1846)	11.9 (11.5 – 12.0)	11.8 (10.9 – 12.0)	11.4 (7.2 – 12.0)
≥ 4 kg	32 (16 – 75)	12 (6 – 37)	274 (124 – 901)	11.9 (11.7 – 12.0)	11.9 (11.4 – 12.0)	11.6 (9.1 – 12.0)

C_max, peak concentrations; C_min, trough concentrations; AUC, area under the concentration vs. time curve; T > MIC, time above the MIC.

Values shown are the mean predictions, 5^th and 95^th percentiles after the first dose.