Table III.
Univariate survival analysis using Kaplan Meier analysis and the log-rank test.
| Characteristic | Median PFS, months | P-value | Median OS, months | P-value |
|---|---|---|---|---|
| Age, years | ||||
| <50 | 7 | 0.262 | 22 | 0.006a |
| ≥50 | 8 | 16 | ||
| Sex | ||||
| Male | 8 | 0.324 | 20 | 0.742 |
| Female | 8 | 18 | ||
| Extent of resection | ||||
| Total | 9 | 0.707 | 21 | 0.063 |
| Partial, biopsy | 6 | 14 | ||
| IMRT/TMZ + cTMZ | ||||
| Completed | 9 | 0.108 | 20 | 0.030a |
| Did not complete | 6 | 14 | ||
| Platelet count | ||||
| No thrombocytopenia | 6 | 0.082 | 20 | 0.928 |
| Thrombocytopenia | 9 | 17 | ||
| WBC count | ||||
| No leukopenia | 6 | 0.088 | 14 | 0.008a |
| Leukopenia | 9 | 21 | ||
| IDH1 status | ||||
| IDH1 wild type (89) | 8 | 0.697 | 16 | 0.287 |
| IDH1 mutation (5) | 13 | 23 | ||
| WBC, absent IDH1 R132H | ||||
| No leukopenia (46) | 6 | 0.116 | 13 | 0.053 |
| Leukopenia (43) | 9 | 20 | ||
| WBC, present IDH1 R132H | ||||
| No leukopenia (2) | 12 | 0.432 | 30 | 0.586 |
| Leukopenia (3) | 13 | 23 | ||
| WBC, incomplete IMRT/TMZ + cTMZ | ||||
| No leukopenia (23) | 5 | 0.035 | 10 | 0.055 |
| Leukopenia (30) | 8 | 17 | ||
| WBC, IMRT/TMZ + cTMZ | ||||
| No Leukopenia (43) | 7 | 0.532 | 16 | 0.048 |
| Leukopenia (45) | 9 | 24 | ||
aP<0.05. For the categories of IDH1 status, WBC with absent IDH1 R132H, WBC with present IDH1 R132H, WBC with incomplete IMRT/TMZ + cTMZ, and WBC with IMRT/TMZ + cTMZ, the values in brackets indicate the number of patients in each subcategory. Patient age, sex, extent of resection, fraction completed 6 weeks of IMRT/TMZ followed by six cycles of adjuvant TMZ, platelet count, WBC count and IDH R132H status were analyzed, PFS, OS and corresponding P-values are shown. Kaplan-Meier analysis with log rank tests was performed using statistical computing language and survival analysis libraries (R version 4.0.2; R Foundation). IMRT/TMZ, intensity-modulated radiation therapy/temozolomide; PFS, progression-free survival; OS, overall survival; WBC, white blood cell count; IDH1, isocitrate dehydrogenase 1.