Table 2.

Comparisons of mean PSR value between several cohorts, all healthy control subjects vs. all MS patients (first column), age-matched healthy controls vs all MS patients (second column), age-matched healthy controls vs. MS patients with high disability (EDSS > 2) (third column), and MS patients with low disability (EDSS ≤ 2) vs. MS patients with high disability (EDSS > 2) (fourth column). A significant reduction was only found for PSR in the motor region when comparing age-matched healthy controls to MS patients with high disability.

Mean PSR Comparison	HC (non-matched) vs. MS		HC vs. MS		HC vs. MS High Disability		MS Low vs. High Disability
cGM Region	Reduction	p-value	Reduction	p-value	Reduction	p-value	Reduction	p-value
Total	−4.31%	0.15	−6.12%	0.11	−7.09%	0.13	−1.34%	0.72
Prefrontal	−3.70%	0.29	−4.84%	0.26	−5.60%	0.41	−1.06%	0.86
Parietal	−5.54%	0.10	−7.48%	0.07	−9.44%	0.10	−2.68%	0.58
Motor	−4.93%	0.20	−9.08%	0.06	−12.10%	0.02	−4.10%	0.37
Sensory	−6.06%	0.12	−8.27%	0.09	−12.40%	0.06	−5.66%	0.33

Comparison Results: PSR in Cortical Gray Matter Regions.