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. 2020 Oct 9;8(2):e000706. doi: 10.1136/jitc-2020-000706

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Tumor-infiltrating lymphocytes (TILs) generated by panning have an optimal phenotype for adoptive transfer. (A) TIL yields from six clear cell renal cell carcinoma samples using the panning, Pre-Rapid Expansion Protocol (PreREP), and fresh tumor digest (FTD)+ beads protocols to expand autologous TILs. (B) Percentage of CD3+ cells in the final TIL products. (C) Frequencies of CD8+, CD4+, double-negative (DN), and double-positive (DP) T cells in the final TIL products. (D) Representative CD103 staining of CD3+/CD8+ T cells in the final TIL products. (E) Frequency of CD103+/CD8+ T cells in the final TIL products. (F) Representative regulatory T cells (T_reg) staining and fluorescence minus one (FMO) controls. (G) Frequencies of CD25+/FOXP3+ T cells within the CD4+ subset in the final TIL products. NS, not significant.