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. 2020 Oct 9;8(2):e000706. doi: 10.1136/jitc-2020-000706

Figure 4.

Figure 4

Tumor-infiltrating lymphocytes (TILs) generated by panning have reduced coexpression of immune checkpoints. (A) Representative T-cell immunoglobulin and mucin-domaincontaining-3 (TIM-3) versus programmed cell death-1 (PD-1) staining of autologous TIL products. (B) Frequency of PD-1+ T cells in the final TIL products. (C) Frequency of TIM-3+ T cells in the final TIL products. (D) Frequency of PD-1+/TIM-3+ double-positive T cells in the final TIL products. (E) Frequency of lymphocyte-activation gene-3 (LAG-3+) T cells in the final TIL products. (F) Representative T-cell immunoreceptor with IG and ITIM domain (TIGIT) staining of autologous TIL products. (G) Frequency of TIGIT+ T cells in the final TIL products. FTD, fresh tumor digest; NS, not significant; PreREP, Pre-Rapid Expansion Protocol.