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. 2020 Oct 9;8(2):e000706. doi: 10.1136/jitc-2020-000706

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Bead-based tumor-infiltrating lymphocyte (TIL) expansion generates TIL products with increased clonal diversity; however, dominant clones are identical and expanded by all methods. (A) Absolute number of productive TCRB CDR3 rearrangements detected in the TIL products expanded by each method. (B) The combined productive frequency of the top 20 clones expanded by each method. (C) The productive Simpson clonality metric for the TIL products expanded by each method. (D) Comparison of clonal frequency for each specimen and method: clear dots represent clones which were too infrequent to be analyzed (each dot may represent multiple clones), gray dots represent clones which were not significantly enriched due to expansion method, blue dots represent clones which were significantly enriched by the method on the x-axis, and red dots represent clones which were significantly enriched by the method on the y-axis. CDR3, complementarity-determining region 3; FTD, fresh tumor digest; NS, not significant; PreREP, Pre-Rapid Expansion Protocol; RCC, renal cell carcinoma; TCR, T-cell receptor.