Table 4.

Risk factors for in-hospital mortality

	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Age >65 years	5.76 (3.46 to 9.60)	<0.0001	3.41 (2.00 to 5.78)	<0.0001
Males	1.58 (1.00 to 2.50)	0.049	1.17 (0.73 to 1.86)	0.52
Exposure to ACE inhibitors	1.68 (1.03 to 2.74)	0.04	1.28 (0.77 to 2.13)	0.34
Exposure to sartan	0.91 (0.52 to 1.61)	0.76
Exposure to ACE inhibitors or sartan	1.33 (0.88 to 2.02)	0.17
Cardiovascular disease	2.49 (1.63 to 3.79)	<0.0001	1.37 (0.88 to 2.13)	0.16
PaO2/FiO2 ≤200 mm Hg	6.68 (4.25 to 10.52)	<0.0001	3.57 (2.20 to 5.77)	<0.0001
Presence of hARF at admission	15.08 (4.78 to 47.59)	<0.001	3.58 (1.05 to 12.18)	0.04
CPAP at admission	2.20 (1.32 to 3.67)	0.002	1.62 (0.96 to 2.72)	0.07

Multivariate Cox regression analysis that identifies risk factors for in-hospital mortality. Data are reported as HR and 95% CIs.

ACEi, ACE inhibitor; CPAP, continuous positive airway pressure; FiO2, fraction of inhaled oxygen; PaO2, arterial partial pressure of oxygen.