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. 2020 Aug 20;8(10):e1453. doi: 10.1002/mgg3.1453

Figure 2.

Figure 2

Developmental and molecular etiology of congenital scoliosis. The illustration demonstrates how genetic mutations identified in TBX6‐mediated genes may alter the process of somitogenesis and whereby cause congenital scoliosis. Arrows between gene symbols indicate activation. The diamond between RIPPLY1/2 and TBX6 indicates a negative feedback between the molecules