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Overview of our investigation to find the etiology of a severe reaction to radiotherapy in a patient with breast cancer. We identified germline biallelic and hypomorphic pathogenic variants in the ATM DNA‐repair gene, as well as an increased serum level of alpha‐fetoprotein. We suggest a routine measurement of alpha‐fetoprotein in radiotherapy‐candidate breast cancer patients followed by next‐generation sequencing with special attention to ATM hypomorphic variants
