Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 1;17(8):1214–1222. doi: 10.1080/15476286.2020.1732694

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 2. — tRF function in epigenetic silencing during early embryogenesis. (A) tRFs mediate intergenerational transmission of metabolic phenotypes. 5ʹ-tRFs including tRF-GG, exhibit a two-three fold increase in somatic epididymis cells upon dietary restriction and are transferred to maturing sperm cells. This process has been proposed to repress endogenous retroelements (RE) and pass paternal inherited information during embryonic development. (B) Murine trophoblastic stem cells produce 3ʹ-tRFs that inhibit the replication of endogenous retroviruses via two distinct mechanisms: (i) putative model illustrating 22 nt 3ʹ-tRFs inducing post-transcriptional silencing of retroviral RNA possibly via association with the canonical miRNA-effector protein AGO2. (ii) 18 nt 3ʹ-tRFs interfere with reverse transcription of viral RNAs to restrict transposon mobility.