Figure 2.

Structural insights into the eIF4E family. Panel A. Structure of apo-eIF4E demonstrating the relative location for the binding of described factors which engage and/or regulate this protein. Panel B. eIF4E/4E-BP1 demonstrates the arrangement of 4E-BP1 on the dorsal surface. Panels C, D and E. Structures of all three members of the eIF4E family demonstrating the similar means by which they bind the m⁷G cap. This same pocket is used to bind TMG cap for eIF4E. PDB codes are as follow: 4UED (B); 3AM7 (C); 2JGB (D); 4B6U (E).