Table 1.

Multiplicity in function of translation initiation factors.

Factor	Translation Function	Other Functions
eIF4E	m7G cap engagement	RNA export, 3ʹend processing, effects on eIF4A helicase activity
CBC	m7G cap engagement	General processing (splicing, export etc.)
eIF3d	m7G cap engagement	Recruitment of 40S ribosome subunit to eIF4F by eIF4G interactions and roles in IRES translation
PARN	m7G cap engagement	Shortening of poly(A) tails of mRNAs
eIF4G	Assembly platform for initiation binding eIF4E and eIF3d
CTIF	Assembly platform for initiation binding CBC and eIF3g
DAP5/p97	Assembly platform for eIF3d or PARN dependent translation	Acts in some forms of IRES dependent translation and others
TRS	Assembly platform for eIF4E2 cap-dependent translation	tRNA synthetase