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tRFs facilitate viral infections. A) 5ʹtRNA half biogenesis increases upon respiratory syncytial virus (RSV) infection to silence the expression of host genes (APOER2) and facilitate viral replication in epithelial cells. B) Hepatitis B and C virus (HV (B, C)) trigger tRNA half biogenesis which in turn facilitate viral replication via an unknown molecular mechanism in hepatocytes.
