Figure 6.

CPSF73 is a drug discovery target.

(a). Chemical structure of JTE-607. (b). Structure of human CPSF73 catalytic module (in color) in complex with the acid form of JTE-607 (in black) [95], overlaid with that in complex with sulfate in a closed form [17]. (c). Chemical structure of the anti-protozoal benzoxaborole AN3661. (d). Binding mode of AN3661 in the active site of C. huminis CPSF73 [102]. The oxaborole moiety competes with the scissile phosphate of the substrate and replaces the bridging ligand between the two zinc ions, which is the nucleophile for the cleavage reaction. The boron atom is in light blue.