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. 2020 Sep 25;16(9):e1009020. doi: 10.1371/journal.pgen.1009020

Fig 9. Schematic representation of the molecular function of TBC1D21 in intra-manchette transport (IMT) during sperm-tail formation.

Fig 9

During sperm-tail formation, several components of the sperm-tail (e.g., mitochondria, fibrous sheath, and ODFs) are delivered via IMT. TBC1D21 and GEFs regulate the levels of bioactive RAB10 by facilitating conversion between activated and inactivated RAB10 (GTP- and GDP-RAB10, respectively). RAB10 acts as a vehicle for the cage (mitochondria) by interacting with TOMM20, while motility is regulated based on its interaction with the molecular motors (e.g., DYNEIN complexes) during IMT, constructed by microtubules. HTCA: head-tail coupling apparatus.