Table 3.
Subgroup Analysis for Thigh Circumference with All-Cause and Cardiovascular Mortality
| Exposure | Number | All-Cause Mortality | Cardiovascular Mortality | ||
|---|---|---|---|---|---|
| HR (95% CI), P-value | P for Interaction | HR (95% CI), P-value | P for Interaction | ||
| Gender | 0.9154 | 0.5927 | |||
| Male | 9531 | 0.97 (0.95,0.98) <0.001 | 0.93 (0.88,0.97) 0.0017 | ||
| Female | 10,354 | 0.97 (0.95,0.98) <0.001 | 0.96 (0.92,1.01) 0.1234 | ||
| Cardiovascular diseases | 0.3566 | 0.3060 | |||
| No | 16,918 | 0.97 (0.96,0.98) <0.001 | 0.95 (0.92,0.99) 0.0057 | ||
| Yes | 738 | 0.97 (0.93,1.00) 0.0664 | 0.93 (0.86,1.01) 0.0956 | ||
| Diabetes | <0.001 | 0.2781 | |||
| No | 17,486 | 0.97 (0.95,0.98) <0.001 | 0.96 (0.92,1.00) 0.0734 | ||
| Yes | 2290 | 0.98 (0.96,0.99) 0.0126 | 0.94 (0.89,0.99) 0.0123 | ||
| Hypertension | 0.0767 | 0.0001 | |||
| No | 13,352 | 0.97 (0.95,0.99) 0.0048 | 0.92 (0.86,0.99) 0.0297 | ||
| Yes | 6447 | 0.97 (0.95,0.98) <0.001 | 0.96 (0.92,0.99) 0.0146 | ||
| Age, years | 0.3528 | 0.2877 | |||
| <50 | 11,725 | 0.90 (0.88,0.93) <0.001 | 0.88 (0.77,0.99) 0.0367 | ||
| ≥50 | 8160 | 0.98 (0.97,0.99) 0.0005 | 0.95 (0.92,0.99) 0.0056 | ||
| BMI, kg/m2 | <0.0001 | <0.0001 | |||
| <25 | 6835 | 0.97 (0.95,1.00) 0.0543 | 0.91 (0.85,0.98) 0.0075 | ||
| ≥25 | 12,940 | 0.97 (0.96,0.98) <0.001 | 0.97 (0.93,1.00) 0.088 | ||
Notes: When analysis a subgroup variable, age, gender, body mass index, total cholesterol, anti-diabetic drugs, estimated glomerular filtration rate, smoking status, alcohol consumption, race, diabetes, hypertension, waist circumference, any cancer at baseline, moderate activity. Cardiovascular diseases were all adjusted except the variable itself.
Abbreviations: HR, hazard ratio; CI, confidence interval; BMI, body mass index.