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Diagnostic performance of chromosome Z-scores. (A) calculation of area under the curve for each chromosome aberration. (B) ROC curve for chr18q. (C) ROC curve for chr7p. (D) Comparison of ROC curves between chromosome Z-scores incorporating all information of copy number aberrations, CA 19-9 and CEA. (E) the adding of Z-scores to CA 19-9 increased the detection rate of bile duct cancer. GBC, gallbladder cancer. CC, cholangiocarcinoma.
