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. 2020 Sep 29;9:e61762. doi: 10.7554/eLife.61762

Figure 1. Cnr1-/-Cnr2-/- females show normal responses to embryonic stimulation during implantation, but decidual process is compromised.

(a) In situ hybridization of Ptgs2 in uteri on day 5 of pregnancy. The expression patterns of Ptgs2 critical for implantation show no significant difference in WT and Cnr1-/-Cnr2-/- females. CK8 staining outlines uterine epithelial cells. (b) In situ hybridization of Bmp2 in uteri on day 5 of pregnancy. Decidual responses in Cnr1-/-Cnr2-/- females are much weaker than those in WT females. le, luminal epithelium; s, stroma; ge, glandular epithelium; Asterisks, positions of embryos; Scale bars, 500 μm. All images are representative of three independent experiments.

Figure 1.

Figure 1—figure supplement 1. In situ hybridization of Hoxa10 in uteri on day 5 of pregnancy.

Figure 1—figure supplement 1.

Decidual responses in Cnr1-/-Cnr2-/- females are weaker than those in WT females. le, luminal epithelium; s, stroma; ge, glandular epithelium; Asterisks, positions of embryos; Scale bars, 500 μm. All images are representative of three independent experiments.