Figure 2. Cnr1-/-Cnr2-/- females have suboptimal decidualization.
(a) 3D visualization of day 6 implantation sites in WT and Cnr1-/-Cnr2-/- females. Images of E-cadherin immunostaining, segmented, and 3D rendered images of day 6 implantation sites in each genotype show compromised decidual responses in Cnr1-/-Cnr2-/- females. Scale bars, 300 μm. (b and c) In situ hybridization of Bmp2 and Ptgs2 in uteri on day 6 of pregnancy. M, mesometrial; AM, anti-mesometrial; Asterisks, positions of embryos; Scale bars, 500 μm. All images are representative of three independent experiments.