Fig. 6.

Regeneration of the foveal shape after closure of a full-thickness macular hole (FTMH) may involve the formation of a glial tissue with medium reflectivity which seals the hole at the outer layers (arrowheads). The months after the first examination (0) are indicated left of the images. a–c Three cases of surgical closure of a FTMH. Vitrectomy with internal limiting membrane peeling was performed one (a), 1.5 (b), and 0.5 months (c) after the first visit, respectively. Scale bars, 200 µm. ELM, external limiting membrane; EZ, ellipsoid zone; GCL, ganglion cell layer; HFL, Henle fiber layer; INL, inner nuclear layer; IPL, inner plexiform layer; IZ, interdigitation zone; NFL, nerve fiber layer; ONL, outer nuclear layer; OPL, outer plexiform layer; RPE, retinal pigment epithelium