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. 2020 Aug 3;72(5):1271–1287. doi: 10.1007/s43440-020-00151-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The effect of a 5-week treatment with imipramine or agomelatine on the intensity of protein bands of cytochrome P450 enzymes (CYP1A, CYP2A, CYP2B, CYP2C6 CYP2C11, CYP2D and CYP3A) in rat liver microsomes from nonstressed (a) and stressed (b) rats. Microsomal proteins were subjected to the Western immunoblot analysis. cDNA-expressed CYP enzymes were used as standards. The representative CYP protein bands in imipramine- or agomelatine-treated rats are shown. The presented results are typical of four separate rats per group. The mean values ± S.E.M. are shown in Figs. 1b, 2b, 3b, 4b, 5b, 6b and 7b. IMI imipramine, AGM agomelatine, STD standard