Table 3.

Statistically significant values of F and p derived from the two-way analysis of variance (ANOVA) carried out to analyze the results of CYP activity levels for: factor I—stressed/nonstressed, factor II—IMI/AGM/saline control, and for the interaction between factors I and II—stressed/nonstressed × IMI/AGM/saline control

CYP	Stressed/nonstressed		IMI/AGM/saline		Stressed/nonstressed × IMI/AGM/saline
	F	p	F	p	F	p
1A	F1,54 = 0.1953 F1,54 = 0.1868	0.660323 0.667319	F2,54 = 9.8423 F2,54 = 4.2945	0.000227 0.018585	F2,54 = 0.0487 F2,54 = 0.4035	0.952490 0.669987
2A	F1,53 = 0.602	0.441280	F2,53 = 27.298	0.000000	F2,53 = 1.459	0.241631
2B	F1,53 = 0.7534	0.389308	F2,53 = 7.4751	0.001381	F2,53 = 0.0056	0.994380
2C6	F1,52 = 1.933	0.170303	F2,52 = 14.051	0.000013	F2,52 = 1.568	0.218204
2C11	F1,50 = 4.6492 F1,45 = 3.0059	0.035904 0.089809	F2,50 = 24.3904 F2,45 = 20.6261	0.000000 0.000000	F2,50 = 0.1450 F2,45 = 0.1266	0.865420 0.881420
2D	F1,52 = 0.9777	0.327337	F2,52 = 65.0573	0.000000	F2,52 = 1.2554	0.293456
3A	F1,48 = 2.825	0.099311	F2,48 = 10.129	0.000214	F2,48 = 0.954	0.392213

The values of F and p marked in bold indicate statistically significant changes in the activity of CYPs within and between studied factors

IMI imipramine, AGM agomelatine