Table 1.
Demographical and baseline characteristics of the patients divided into two groups according to whether the achieved reduction in hsCRP at 6 months from baseline was equal to or greater than 40% (responder), or less than 40% (non-responder).
| Male (n = 673) | Female (n = 490) | |||||
|---|---|---|---|---|---|---|
| Responder (n = 192) | Non-responder (n = 481) | P value | Responder (n = 123) | Non-responder (n = 367) | P value | |
| hsCRP (mg/L) | 1.31 (0.61–3.40) | 0.50 (0.26–0.91) | < 0.0001 | 0.98 (0.54–2.31) | 0.44 (0.21–0.97) | < 0.0001 |
| Age (years) | 64.5 ± 8.9 | 65.0 ± 10.1 | 0.2738 | 69.0 ± 8.3 | 68.3 ± 8.2 | 0.3492 |
| BMI (kg/m2) | 25.2 ± 3.3 | 25.1 ± 3.6 | 0.7201 | 25.0 ± 4.3 | 25.5 ± 4.2 | 0.2125 |
| Systolic BP (mmHg) | 150.5 ± 14.3 | 150.7 ± 16.3 | 0.9139 | 150.7 ± 14.3 | 149.0 ± 15.7 | 0.3111 |
| Diastolic BP (mmHg) | 86.1 ± 10.4 | 85.7 ± 11.6 | 0.6542 | 82.6 ± 12.1 | 80.9 ± 11.8 | 0.0991 |
| Heart rate (b.p.m) | 73.2 ± 12.9 | 71.8 ± 11.0 | 0.2403 | 73.0 ± 10.0 | 71.8 ± 10.5 | 0.1570 |
| Diabetes mellitus, n (%) | 134 (69.8) | 311 (64.7) | 0.2038 | 82 (66.7) | 258 (70.3) | 0.4493 |
| Hyperlipidemia, n (%) | 104 (54.2) | 248 (51.6) | 0.5408 | 88 (71.5) | 239 (65.1) | 0.1908 |
| Current smoker, n (%) | 46 (24.0) | 131 (27.2) | 0.3833 | 14 (11.4) | 63 (17.2) | 0.1271 |
| Previous cardiovascular disease, n (%) | 104 (54.2) | 293 (60.9) | 0.1080 | 63 (51.2) | 191 (52.0) | 0.8742 |
| Allocation to ARB therapy, n (%) | 104 (54.2) | 234 (48.6) | 0.1961 | 60 (48.8) | 181 (49.3) | 0.9177 |
| Total cholesterol (mg/dL) | 191.9 ± 35.3 | 193.8 ± 38.3 | 0.4776 | 200.4 ± 34.8 | 198.2 ± 32.1 | 0.8763 |
| LDL cholesterol (mg/dL) | 109.5 ± 28.3 | 111.6 ± 30.2 | 0.4008 | 114.8 ± 31.6 | 112.6 ± 27.5 | 0.6998 |
| HDL cholesterol (mg/dL) | 54.8 ± 15.1 | 54.4 ± 13.5 | 0.7850 | 58.5 ± 12.4 | 58.5 ± 13.2 | 0.8984 |
| Blood sugar (mg/dL) | 142.5 ± 60.0 | 135.4 ± 57.4 | 0.0327 | 124.1 ± 43.9 | 132.0 ± 52.9 | 0.3253 |
| Hemoglobin A1c (%) | 6.5 ± 1.2 | 6.3 ± 1.1 | 0.0626 | 6.3 ± 1.1 | 6.3 ± 1.1 | 0.6009 |
| Plasma BNP (pg/mL) | 16.4 (8.4–31.6) | 15.5 (7.5–34.5) | 0.4928 | 19.9 (11.3–44.2) | 21.6 (11.7–38.9) | 0.8509 |
| UACR (mg/g creatinine) | 31.7 (11.2–106.8) | 23.00 (9.8–81.8) | 0.1656 | 30.9 (14.9–89.4) | 25.4 (11.6–81.9) | 0.2221 |
| eGFR (ml/min per 1.73 m2) | 72.1 (62.1–88.5) | 71.2 (59.6–83.5) | 0.1019 | 70.2 (60.7–84.3) | 71.0 (58.6–84.7) | 0.5547 |
| HMW adiponectin (μg/mL) | 2.7 ± 2.9 | 2.7 ± 2.7 | 0.2046 | 4.2 ± 3.1 | 4.7 ± 4.5 | 0.5431 |
| Total adiponectin (μg/mL) | 5.4 ± 3.6 | 5.5 ± 3.8 | 0.1994 | 7.3 ± 4.1 | 8.1 ± 5.5 | 0.3329 |
| Urinary 8-OHdG (ng/mL) | 11.2 (7.0–16.9) | 10.4 (6.3–15.4) | 0.1208 | 9.5 (5.7–14.2) | 7.9 (4.5–13.0) | 0.0757 |
| Hemoglobin (g/dL) | 14.6 ± 1.38 | 14.6 ± 1.45 | 0.9598 | 13.0 ± 1.3 | 13.0 ± 1.3 | 0.4404 |
| White blood cell (/μL) | 6149 ± 1495 | 6075 ± 1614 | 0.3179 | 5924 ± 1662 | 5881 ± 1590 | 0.9094 |
| Creatinine (mg/dL) | 0.86 ± 0.25 | 0.88 ± 0.23 | 0.0885 | 0.65 ± 0.17 | 0.67 ± 0.18 | 0.5790 |
| Potassium (mEq/L) | 4.24 ± 0.45 | 4.29 ± 0.51 | 0.3376 | 4.35 ± 0.51 | 4.32 ± 0.55 | 0.3246 |
| Uric acid (mg/dL) | 5.7 ± 1.4 | 5.7 ± 1.3 | 0.9089 | 4.8 ± 1.3 | 4.8 ± 1.2 | 0.9147 |
Responder indicates the group in whom reduction of hsCRP at 6 months from baseline was equal to or greater than 40%, while Non-responder indicates the group in whom reduction of hsCRP at 6 months from baseline was less than 40%.
hsCRP, plasma BNP, UACR, eGFR, and urinary 8-OHdG are expressed as median with interquartile range. Other data are mean ± s.d. for continuous values and number (%) for categorical variables.
hsCRP high-sensitivity C-reactive protein, BMI Body Mass Index, BP blood pressure, ARB therapy antihypertensive treatment with angiotensin II receptor blocker, LDL low-density lipoprotein, HDL high-density lipoprotein, BNP brain natriuretic peptide, UACR urinary albumin/creatinine ratio, eGFR estimated glomerular filtration rate, HMW adiponectin high-molecular weight adiponectin, 8-OHdG 8-hydroxy-2′-deoxyguanosine.
P-value was calculated using unpaired t test or Mann–Whitney test for continuous variables and χ2 test for categorical variables.