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. 2020 Oct 12;10:17012. doi: 10.1038/s41598-020-73896-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mitochondrial superoxide was quantified in platelets and PBMCs from Simvastatin users (N = 34) and controls (N = 15) (A and C). Where indicated, Simvastatin users were stratified according to presence (N = 12) or absence (N = 22) of self-reported myalgia (B, D). Values shown are mean ± S.E.M. A subset of 24 Simvastatin users were dosed with placebo (E, H; N = 11) or Q10 (F, G, I, J; N = 13) for 8 weeks. Platelets (E–G) and PBMCs (H–J) were isolated and analyzed for mitochondrial superoxide before and after treatment, as indicated. Q10-treated patients were stratified according to the presence (N = 6) or absence of myalgia, as indicated (G, J). Mitochondrial superoxide was measured in arbitrary units (A.U.) and values shown are mean ± S.E.M.