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. 2020 Oct 12;10:16385. doi: 10.1038/s41598-020-73315-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Senescence markers were elevated in human DMD patients. (a–c) Quantification of mRNA levels of senescence markers (p16, p14, and p21) in non-DMD control individuals and patients with DMD. Individual data from non-DMD control individuals and DMD patients are expressed as bar graphs (n = 10, 35). The grey band behind the graph indicates the mean ± SEM value range of the non-DMD control group. The figure without a grey band indicate that the target gene expression was not observed in the non-DMD control group. (d,e) Skeletal muscle sections from DMD patients were subjected to in situ hybridisation of CDKN2A mRNA using RNAscope before immunocytochemical analysis of (d) Pax7 or (e) PDGFRα with laminin. CDKN2A mRNA appears as brown dots. Scale bar = 10 μm. White arrowheads indicate DAB signal. N.D. not detected.