Table 5.
Comparison of differences between pre- and post-treatment in performed CXL protocols. Significance is marked in italics
| Parameter | Difference of S-CXL (3*30) |
Difference of A-CXL (9*10) |
Difference of A-CXL (18*5) |
P value (3*30–9*10) |
P value (3*30–18*5) |
P value (9*10–18*5) |
|---|---|---|---|---|---|---|
| CVS-IOP [mmHg] | + 2.97 ± 0.76 | + 2.03 ± 0.79 | + 1.14 ± 1.04 | 0.006 | 0.000 | 0.011 |
| CVS-CT [μm] | − 56.83 ± 55.13 | − 25.06 ± 58.8 | − 43.17 ± 25.43 | 0.169 | 1.000 | 0.812 |
| A1 velocity [m/s] | − 0.02 ± 0.01 | − 0.01 ± 0.01 | − 0.01 ± 0.01 | 0.973 | 0.258 | 1.000 |
| Deflection Amp [mm] | − 0.17 ± 0.04 | − 0.14 ± 0.05 | − 0.09 ± 0.09 | 0.575 | 0.001 | 0.042 |
| DA ratio 2 mm [mm] | + 0.31 ± 0.16 | + 0.09 ± 0.23 | + 0.19 ± 0.23 | 0.009 | 0.287 | 0.496 |
| Integrated radius [mm^-1] | − 0.83 ± 0.36 | − 0.74 ± 0.36 | − 0.59 ± 0.55 | 1.000 | 0.344 | 0.912 |
| SP A1 [mmHg/mm] | + 24.66 ± 9.27 | + 17.81 ± 10.07 | + 8.08 ± 8.78 | 0.100 | 0.000 | 0.009 |
| Kc[mean] [N/m] | + 13.46 ± 18.63 | + 13.7 ± 8.64 | + 6.7 ± 11.42 | 1.000 | 0.423 | 0.383 |
| Kc[linear] [N/m] | + 12.23 ± 15.83 | + 12.64 ± 6.45 | + 6.26 ± 10.25 | 1.000 | 0.376 | 0.306 |
A-CXL accelerated CXL, A1 applanation 1, adj adjusted, Amp amplitude, CT corneal thickness measured by Corvis ST, CVS Corvis ST, CVS-IOP uncorrected Corvis ST IOP, CXL corneal cross-linking, IOP intraocular pressure, DA deformation amplitude, Kc corneal stiffness derived from waveform analysis, S-CXL standard CXL, SE standard error, SP A1 stiffness parameter at 1st applanation