TABLE 1.

Roles of Dok-3 and their interacting partners in B cells, macrophages, neutrophils, osteoclasts, osteoblasts, and lung epithelial cells.

Cell type	Activating/inhibitory	Function	Interacting partner	Mode of identification	References
B-cells	Activating	Promotes plasma cell differentiation	–	–	(16)
		Facilitates movement of BCR	Grb2	Immuno-precipitation	(15)
		microclusters for antigen gathering	Cbl
	Inhibitory	Inhibits BCR signaling	SHIP	Immuno-precipitation, in vitro binding assay	(8)
			Csk	Yeast two-hybrid, immuno-precipitation
			Lck	In vitro overexpression
			Fyn
			Lyn
		Inhibits Ras-MAPK pathway to suppress transformation	Abl	Yeast two-hybrid, immuno-precipitation	(7)
		Limits intracellular calcium signaling	Grb2	Affinity Capture-MS	(13)
			Lyn	Affinity Capture-Western
		Limits production of IgM and proliferative capacity in response to T-cell-independent type I and II antigens	–	–	(11)
Neutrophils	Inhibitory	Inhibits Card9 signaling in response	Card9	Immuno-precipitation	(21)
		to fungal infection	PP1
Macrophages	Activating	Promotes IFN-β production during	BTK	Immuno-precipitation	(20)
		viral infection	TRAF3
			TBK1
	Inhibitory	Inhibits TLR4 signaling	DAP12	Immuno-precipitation	(17, 18)
			Grb2
			SOS1
			Cbl-b
		Negatively regulates IL-6 and TNF-α production during TLR9 signaling	TRAF6	Immuno-precipitation	(19)
		Inhibits malignant transformation together with Dok-1 and Dok-2	–	–	(24)
Osteoblasts and osteoclasts	Activating	Promotes osteoblastogenesis	DAP12	Immuno-precipitation	(22)
	Inhibitory	Inhibits osteoclastogenesis	Grb2
			Cbl
Lung epithelial cells	Inhibitory	Inhibits lung tumorigenesis together with Dok-1 and Dok-2	–	–	(26)
		Inhibits pulmonary inflammation together with Dok-1 and Dok-2	–	–	(27)