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. 2020 Sep 29;8:580933. doi: 10.3389/fcell.2020.580933

FIGURE 4.

FIGURE 4

Pterostilbene treatment ameliorates the myopathic phenotype of Col6a1–/– mice. (A) Representative fluorescence microscopy images of TA cross sections of Col6a1–/– mice treated for 5 days with vehicle or with Pt (90.2 mg/kg body weight) and stained for apoptotic nuclei (TUNEL assay, red) and Hoechst (blue). White arrowheads indicate TUNEL-positive nuclei. Scale bar, 100 μm. (B) Quantification of TUNEL-positive myonuclei in TA cross sections from Col6a1–/– mice treated with by oral gavage for 5 days with vehicle or with Pt (90.2 mg/kg body weight). Data are shown as mean ± s.e.m. (n = 4; **P < 0.01). (C–H) Transmission electron microscopy images of TA longitudinal sections from Col6a1–/– mice treated by oral gavage for 5 days with vehicle (C–E) or with Pt (90.2 mg/kg body weight) (F–H). Scale bar, 1 μm. ap, autophagosome; m, mitochondrion; mvb, multivesicular body; Veh, vehicle.