Table 6.

Selected mean hematology and clinical chemistry parameters in beagle cross dogs (mixed gender) taken pre-CHE treatment and post-fifth medium CHE dose (5 mg CBD/kg bw).

Test	Units	Reference	Mean pre-treatment	Mean post-treatment	Mean change	% Difference
Sodium	mmol/L	140–153	147.1	146.3	−0.8	−1
Potassium	mmol/L	3.8–5.6	4.5	4.5	0.0	1
Na:K ratio		28–38	33.1	32.5	−0.6	−2
Chloride	mmol/L	105–120	110.4	108.8	−1.6	−1
Bicarbonate	mmol/L	15–25	20.5	18.4	−2.1*	−10
Anion gap	mmol/L	12–26	20.7	23.7	3.0**	15
Calcium	mmol/L	1.91–3.03	2.6	2.6	0.0	0
Phosphorus	mmol/L	0.63–2.41	1.2	1.5	0.3*	23
Magnesium	mmol/L	0.70–1.16	0.9	0.9	0.0	1
Urea	mmol/L	3.5–11.4	4.5	5.0	0.5*	12
Creatinine	μmol/L	41–121	74.3	72.4	−1.8	−2
Amylase	U/L	343–1,375	707.1	710.2	3.1	0
Lipase	U/L	25–353	86.2	81.0	−5.2	−6
Glucose	mmol/L	3.1–6.3	5.1	5.2	0.2	3
Cholesterol	mmol/L	2.70–5.94	5.0	4.8	−0.1	−2
Total bilirubin	μmol/L	1.0–4.0	1.7	1.2	−0.6**	−33
Direct bilirubin	μmol/L	0–2	0.8	0.6	−0.1**	−18
Indirect bilirubin	μmol/L	0–2.5	1.0	0.5	−0.4**	−46
Alkaline phosphatase	U/L	9–90	51.3	56.9	5.7	11
γ-Glutamyl transferase	U/L	0–8	4.9	2.8	−2.1**	−42
Alanine aminotransferase	U/L	19–59	46.2	41.3	−4.9	−11
Glutamate dehydrogenase	U/L	0–7	3.3	3.4	0.2	5
Creatinine kinase	U/L	51–418	126.8	98.3	−28.4**	−22
Total protein	g/L	55–71	58.5	56.2	−2.3	−4
Albumin	g/L	32–42	36.7	36.1	−0.6	−2
Globulin	g/L	20–34	21.8	20.1	−1.8	−8
A:G ratio		1.06–1.82	1.7	1.8	0.1	7
Leukocytes	×109/L	4.9–15.4	7.9	8.0	0.1	2
Segmented neutrophils	×109/L	3.0–10.0	4.7	4.9	0.2	5
Eosinophils	×109/L	0–1.1	0.7	0.6	−0.2	−22
Lymphocytes	×109/L	1.2–5.0	2.0	2.1	0.1	4
Monocytes	×109/L	0.08–1.0	0.5	0.5	0.0	−3
Erythrocytes	×1012/L	5.8–8.5	7.3	6.4	−0.9	−12

^*p < 0.05, paired t-test (normal distribution).

^**p < 0.05, Wilcoxon rank sum test (non-normal distribution).