Table 2.

Survival analysis in terms of overall survival.

Parameters	Overall survival			Univariate analysis		Multivariate analysis
				HR(95%CI)	p	HR(95%CI)	p
Primary treatment	1-year OS	3-year OS	5-year OS		<0.001		0.001
SR	87.4	73.3	61.5	Reference		Reference
RFA	89.9	42.4	23.9	2.76 (1.61–4.73)		3.26 (1.58–6.51)
Race					0.084		0.698
White	97.1	82.7	70.3	Reference		Reference
Black	93.3	70.5	52.9	1.27 (0.44–3.68)		1.24 (0.41–3.66)
Other	84.5	62.4	49.9	1.96 (1.01–3.80)		2.12 (1.08–4.17)
Gender					0.880
Male	86.4	66.5	56.1	Reference
Female	89.7	68.7	53.7	0.96 (0.59–1.57)
Year of diagnosis					0.321
2004–2007	72.2	58.2	46.6	Reference
2008–2011	88.2	69.5	58.5	0.68 (0.40–1.18)
2012–2014	85.7	77.2	–	0.58 (0.24–1.42)
Age at diagnosis					0.325
≤ 60	89.6	64.9	56.6	Reference
60–70	86.2	72.2	59.1	0.79 (0.43–1.44)
>70	81.0	65.3	46.7	1.28 (0.71–2.28)
Marital status					0.082		0.803
Married	89.7	73.2	56.9	Reference		Reference
Divorced	90.0	73.4	64.2	0.79 (0.33–1.88)		0.89 (0.37–2.14)
Single or widowed	83.1	52.3	45.8	1.11 (0.54–2.24)		1.07 (0.52–2.21)
Tumor size (cm)					0.032		0.046
<3	85.6	75.4	62.9	Reference		Reference
3–5	89.6	61.2	48.4	1.60 (1.26–2.39)		1.71 (1.01–2.90)
Tumor grade					0.051		0.295
Grade I–II	93.4	72.7	65.2	Reference		Reference
Grade III	85.5	61.1	55.5	1.42 (0.73–2.76)		1.42 (0.73–2.77)
Unknown	85.7	61.2	44.7	1.99 (1.15–3.45)		1.25 (0.66–2.37)
Radiation					0.271
Yes	83.3	75.0	66.7	Reference
No/unknown	88.3	66.6	53.2	1.69 (0.61–4.65)
Chemotherapy					0.932
Yes	80.3	63.8	59.5	Reference
No/unknown	90.0	67.3	53.3	1.02 (0.56–1.85)

HR, hazard ratio; CI, confidence interval; SR, surgical resection; RFA, radiofrequency ablation; OS, overall survival.