Table 3.

Survival analysis in terms of cancer-specific survival.

Parameters	Cancer-specific survival			Univariate analysis		Multivariate analysis
				HR(95%CI)	p	HR(95%CI)	p
Primary treatment	1-year CSS	3-year CSS	5-year CSS		<0.001		0.001
SR	91.5	73.8	66.1	Reference		Reference
RFA	93.5	53.4	30.0	2.87 (1.57–5.24)		3.82 (1.72–8.44)
Race					0.557
White	–	89.0	75.6	Reference
Black	93.3	75.5	56.6	1.43 (0.43–4.76)
Other	88.4	69.7	52.6	2.27 (1.06–4.89)
Gender					0.695
Male	92.8	75.8	64.0	Reference
Female	90.7	72.6	54.7	1.11 (0.64–1.92)
Year of diagnosis					0.058		0.341
2004–2007	82.6	71.4	57.1	Reference		Reference
2008–2011	94.7	74.7	61.6	0.92 (0.49–1.72)		0.73 (0.38–1.38)
2012–2014	89.5	80.5	–	0.70 (0.24–2.03)		0.65 (0.22–1.88)
Age at diagnosis					0.161
≤ 60	94.9	68.1	59.4	Reference
60–70	93.9	81.3	66.5	0.60 (0.30–1.22)
>70	85.0	70.5	53.1	1.19 (0.63–2.24)
Marital status					0.713
Married	92.6	78.9	61.3	Reference
Divorced	–	77.3	67.6	0.83 (0.32–2.15)
Single or widowed	86.2	62.3	54.6	1.52 (0.83–2.76)
Tumor size (cm)					0.028		0.041
<3	90.0	82.0	68.4	Reference		Reference
3–5	92.5	73.2	53.8	1.68 (1.24–2.72)		1.86 (1.02–3.38)
Tumor grade					0.035
Grade I–II	93.4	76.6	68.8	Reference		Reference
Grade III	91.2	69.8	63.4	1.36 (0.84–2.66)		1.33 (0.63–2.81)
Unknown	90.6	72.4	43.7	1.93 (1.05–3.56)		1.17 (0.58–2.36)
Radiation					0.568
Yes	83.3	75.0	66.7	Reference
No/unknown	92.6	74.0	59.1	1.34 (0.48–3.73)
Chemotherapy					0.573
Yes	82.9	69.6	61.5	Reference
No/unknown	94.5	75.6	59.8	0.83 (0.44–1.56)

HR, hazard ratio; CI, confidence interval; SR, surgical resection; RFA, radiofrequency ablation; CSS, cancer-specific survival.