TABLE 4.

sNfL dependencies.

	Unadjusted effect			Adjusted effect
	R2	Beta	p-value	Model 1 (R2 0.201)		Model 2 (R2 0.301)
				Beta	p-value	Beta	p-value
Seizures	0.013	−0.114	0.159
Male gender	0.001	−0.027	0.736	0.232	0.035	0.300	0.005
Age	0.165	−0.406	<0.001	−0.337	0.002	−0.375	0.001
Body weight	0.139	−0.373	<0.001
Temperature at home	0.012	0.110	0.235
Temperature at ED	0.007	0.086	0.288
Hct	0.011	−0.107	0.195
WBC	0.002	−0.050	0.566
Na	0.005	−0.069	0.437
Cl	0.001	0.002	0.979
pH	0.051	0.227	0.010
CO2	0.019	−0.138	0.121
Bicarbonate	0.013	0.115	0.199
Lactate	0.008	−0.088	0.327
CRP	0.008	0.089	0.310	0.278	0.012	0.241	0.023
Prolactin	0.001	0.016	0.843
Copeptin	0.056	−0.237	0.003			−0.318	0.003

The unadjusted effect of each parameter was calculated by simple linear regression analysis using sNfL values (after logarithmic transformation) as the dependent variable. Significant (p-value < 0.05) parameters of the unadjusted effect are displayed in bold. The adjusted effect was calculated by stepwise linear regression analysis. CRP, C reactive protein; ED, emergency department; sNfL, serum neurofilament light chain; WBC, white blood cell.