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. 2020 Sep 29;11:568637. doi: 10.3389/fimmu.2020.568637

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Copyright © 2020 Hua, Chen, Fu, Chen, Xu, Yang, Chen and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CTCF alters histone H3K9ac and H3K14ac levels in the p53 promoter. (A,B) ChIP-qPCR analysis of the enrichment of histone H3K9ac and H3K14ac levels in the p53 promoter region in normal CD4⁺ T cells transfected with pCMV6-CTCF (A) or pRS-CTCF (B). Values are relative to those obtained with input DNA prepared from untreated chromatin. Data are mean ± SD from three independent experiments. (C,D) ChIP-qPCR analysis of the enrichment of histone H3K9ac (C) and H3K14ac (D) levels in the p53 promoter region in CD4⁺ T cells from patients with aGVHD (n = 15) and individuals without aGVHD (n = 15). Values are relative to those obtained with input DNA prepared from untreated chromatin. (E,F) Correlation analysis of H3K9ac (E)/H3K14ac (F) of p53 promoter and p53 expression in aGVHD CD4⁺ T cells (n = 15).^∗P < 0.05, ^∗∗P < 0.01.