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. 2020 Sep 29;11:568637. doi: 10.3389/fimmu.2020.568637

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Copyright © 2020 Hua, Chen, Fu, Chen, Xu, Yang, Chen and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Restoring CTCF expression in CD4⁺ T cells from aGVHD cases improves Treg/Th17 cell imbalance by increasing p53 expression. (A,B) ChIP-qPCR analysis of the enrichment of p300 binding (A) and H3K9/K14 (B) acetylation levels in the p53 promoter region in CD4⁺ T cells from three separate aGVHD cases after CTCF overexpression. Values are relative to those obtained with input DNA prepared from untreated chromatin. Data are mean ± SD from three independent experiments. (C,D) Real-time PCR analysis of p53, Foxp3, IL-10 (C), RORγt, and IL-17A (D) expression levels in CD4⁺ T cells from three separate aGVHD cases after CTCF overexpression. Data are mean ± SD from three independent experiments. ^∗P < 0.05, ^∗∗P < 0.01.