Table 2.
Association of ERP29 rs7114 genotypes, clinical and tumor characteristics of 250 oropharynx squamous cell carcinoma patients.
| Characteristics | n | ERP29 rs7114 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| AA | AG | GG | AA or AG | GG | AA | AG or GG | |||
| Sex | 250 | ||||||||
| Male | 228 | 135 (59.2%) | 79 (34.6%) | 14 (6.2%) | 214 (93.8%) | 14 (6.2%) | 135 (59.2%) | 93 (40.8%) | |
| Female | 22 | 15 (68.2%) | 5 (22.7%) | 2 (9.1%) | 20 (90.9%) | 2 (9.1%) | 15 (68.2%) | 7 (31.8%) | |
| p-value | Reference | 0.33 | 0.67 | Reference | 0.63 | Reference | 0.49 | ||
| Tobacco consumption | 250 | ||||||||
| Smokers | 224 | 135 (60.3%) | 76 (33.9%) | 13 (5.8%) | 211 (94.2%) | 13 (5.8%) | 135 (60.3%) | 89 (39.7%) | |
| Non-smokers | 26 | 15 (57.7%) | 8 (30.7%) | 3 (11.6%) | 23 (88.5%) | 3 (11.5%) | 15 (57.7%) | 11 (42.3%) | |
| p-value | Reference | 1.00 | 0.38 | Reference | 0.22 | Reference | 0.83 | ||
| Alcohol consumption | 250 | ||||||||
| Drinkers | 197 | 118 (59.9%) | 69 (35.0%) | 10 (5.1%) | 187 (94.9%) | 10 (5.1%) | 118 (59.9%) | 79 (40.1%) | |
| Abstainers | 53 | 32 (60.4%) | 15 (28.3%) | 6 (11.3%) | 47 (88.7%) | 6 (11.3%) | 32 (60.4%) | 21 (39.6%) | |
| p-value | Reference | 0.61 | 0.20 | Reference | 0.11 | Reference | 1.00 | ||
| Histological grade | 211* | ||||||||
| Well or moderately | 176 | 104 (59.1%) | 59 (33.5%) | 13 (7.4%) | 163 (92.6%) | 13 (7.4%) | 104 (59.1%) | 72 (40.9%) | |
| Poorly or undifferentiated | 35 | 19 (54.3%) | 14 (40.0%) | 2 (5.7%) | 33 (94.3%) | 2 (5.7%) | 19 (54.3%) | 16 (45.7%) | |
| p-value | Reference | 0.55 | 1.00 | Reference | 1.00 | Reference | 0.70 | ||
| Tumor stage | 245* | ||||||||
| I or II | 21 | 10 (47.6%) | 11 (52.4%) | 0 (0.0%) | 21 (100.0%) | 0 (0.0%) | 10 (47.6%) | 11 (52.4%) | |
| III or IV | 224 | 137 (61.5%) | 71 (31.4%) | 16 (7.1%) | 208 (92.9%) | 16 (7.1%) | 137 (61.5%) | 87 (38.5%) | |
| p-value | Reference | 0.15 | 0.60 | Reference | 0.37 | Reference | 0.25 | ||
| Tumor localization | 245** | ||||||||
| Base of tongue | 116 | 67 (57.8%) | 41 (35.3%) | 8 (6.9%) | 108 (93.1%) | 8 (6.9%) | 67 (57.7%) | 49 (42.3%) | |
| Tonsillar complex | 84 | 52 (61.9%) | 26 (30.9%) | 6 (7.2%) | 78 (92.9%) | 6 (7.1%) | 52 (61.9%) | 32 (38.1%) | |
| Soft palate | 45 | 27 (60.0%) | 16 (35.5%) | 2 (4.5%) | 43 (95.5%) | 2 (4.5%) | 27 (60.0%) | 18 (40.0%) | |
| p-value | Reference | 0.80 | 0.83 | Reference | 0.82 | Reference | 0.83 | ||
n number of patients.
*The number of patients differed from the total quoted in the study (n = 250), because it was not possible to obtain consistent information about histological grade and tumor stage in some cases.
**The number of patients differed from the total quoted in the study (n = 250), because it was considered for analysis only the most frequent tumor localization.