Table 3.
Association of age, tumor characteristics and ERP29 rs7114 genotypes with survival of 102 base of tongue squamous cell carcinoma patients in Cox analysis.
| Variables | N | Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Event-free survival | Overall survival | Event-free survival | Overall survival | ||||||
| OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | ||
| Age (years) | 102 | ||||||||
| ≤ 57 | 48 | 1.12 (0.69–1.82) | 0.62 | 1.01 (0.65–1.56) | 0.95 | NA | NA | ||
| > 57 | 54 | Reference | Reference | ||||||
| Sex | 102 | ||||||||
| Male | 93 | 1.31 (0.52–3.28) | 0.55 | 1.38 (0.60–3.19) | 0.44 | NA | NA | ||
| Female | 9 | Reference | Reference | ||||||
| Histological grade | 83* | ||||||||
| Well or moderately | 66 | Reference | 0.93 | Reference | 0.40 | NA | NA | ||
| Poorly or undifferentiated | 17 | 1.03 (0.52–2.00) | 1.29 (0.70–2.38) | ||||||
| Tumor size | 101* | ||||||||
| T1 or T2 | 14 | Reference | 0.10 | Reference | 0.02 | Reference | 0.12 | Reference | 0.02 |
| T3 or T4 | 87 | 1.91 (0.87–4.19) | 2.33 (1.12–4.84) | 1.85 (0.83–4.08) | 2.36 (1.13–4.92) | ||||
| Nodal stage | 102 | ||||||||
| N0 or N1 | 40 | Reference | 0.01 | Reference | 0.11 | Reference | 0.03 | Reference | 0.10 |
| N2 or N3 | 62 | 1.85 (1.10–3.12) | 1.43 (0.91–2.24) | 1.77 (1.04–2.99) | 1.45 (0.92–2.27) | ||||
| ERP29 rs7114 | 102 | ||||||||
| AA | 59 | Reference | 0.88 | Reference | 0.55 | NA | NA | ||
| AG or GG | 43 | 1.03 (0.64–1.68) | 1.14 (0.73–1.76) | ||||||
| AA or AG | 95 | Reference | 0.01 | Reference | 0.21 | Reference | 0.04 | NA | |
| GG | 7 | 2.60 (1.17–5.76) | 1.64 (0.74–3.59) | 2.31 (1.03–5.15) | |||||
n number of patients, OR odds ratio, CI confidence interval.
*The number of patients differed from the total quoted in the survival analysis (n = 102), because it was not possible to obtain consistent information in some cases.
The significant values are indicated by bold letters.