Table 1.

Multivariable analysis for LFS and OS in the 79 JAK2-mutated PMF patients, adopting DIPSS-plus, ASXL1 mutation and JAK2 allele burden, and other HMR gene mutations as variables.

	LFS 95% CI				OS 95% CI
Variable	HR	Lower	Upper	P	HR	Lower	Upper	P
DIPSS-plusa	1.984	0.981	4.012	0.057	2.034	0.983	4.212	0.056
ASXL1/JAK2 allele burdenb	2.061	1.015	4.186	0.045	2.361	1.206	4.624	0.012
EZH2	1.932	0.456	8.181	0.371	1.567	0.384	6.388	0.531
SRSF2	2.074	0.414	10.394	0.375	1.504	0.324	6.979	0.602
IDH	2.319	0.079	68.062	0.626	4.134	0.152	112.1	0.399

P values < 0.05 are considered statistically significant.

HMR high-molecular risk, HR hazard ratios, CI confidence interval.

^aDIPSS-plus: low vs. intermediate-1 vs. intermediate-2 vs. high-risk groups.

^bASXL1 mutation with low JAK2 allele burden (<75%) versus others.