Table 2.
Univariable and multivariable Cox models for OS and PFS according to clinical parameters and sHE4 levels of UCC patients.
| No. of patients | No. of events | OS | PFS | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OS | PFS | HR | CI95% | p-value | HR | CI95% | p-value | ||
| Age (years) | 109 | 37 | 43 | 1.05 | 1.02–1.08 | <0.001 | 1.05 | 1.02–1.08 | <0.001 |
| Histological type | |||||||||
| SCC | 73 | 28 | 32 | 1 | |||||
| Non-SCC | 36 | 9 | 11 | 0.61 | 0.29–1.30 | 0.200 | 0.66 | 0.33–1.31 | 0.236 |
| Grading WHO | |||||||||
| G1/G2 | 44 | 11 | 13 | 1 | |||||
| G3 | 55 | 20 | 23 | 1.73 | 0.83–3.61 | 0.145 | 1.72 | 0.87–3.40 | 0.117 |
| FIGO stage | |||||||||
| I | 67 | 9 | 14 | 1 | |||||
| >I | 42 | 28 | 29 | 7.90 | 3.70–16.88 | <0.001 | 5.49 | 2.88–10.47 | <0.001 |
| Clinical tumor size | |||||||||
| ≤ 4 cm | 49 | 4 | 8 | 1 | |||||
| >4 cm | 35 | 19 | 21 | 8.46 | 2.87–24.97 | <0.001 | 4.98 | 2.20–11.29 | <0.001 |
| Lymph-vascular space invasion | |||||||||
| Absent | 17 | 3 | 5 | 1 | |||||
| Present | 37 | 4 | 6 | 0.60 | 0.14–2.70 | 0.508 | 0.51 | 0.16–1.68 | 0.270 |
| Stromal Infiltration | |||||||||
| <3 mm | 5 | 0 | 1 | – | |||||
| ≥3 mm | 48 | 4 | 8 | – | – | 0.500$ | 0.76 | 0.10–6.12 | 0.800 |
| Parametrial invasion | |||||||||
| Absent | 47 | 3 | 7 | 1 | |||||
| Present | 9 | 3 | 4 | 6.34 | 1.28–31.55 | 0.024 | 3.59 | 1.05–12.3 | 0.042 |
| Vaginal invasion | |||||||||
| Absent | 43 | 4 | 7 | 1 | |||||
| Present | 14 | 3 | 5 | 2.62 | 0.59–11.73 | 0.207 | 2.71 | 0.86–8.54 | 0.090 |
| Lymph nodes status | |||||||||
| Negative | 39 | 1 | 5 | 1 | |||||
| Positive | 18 | 6 | 7 | 15.28 | 1.84–127.0 | 0.012 | 3.65 | 1.16–11.52 | 0.027 |
| First line treatment | |||||||||
| Surgery | 58 | 7 | 12 | 1 | |||||
| Chemo/radio | 51 | 30 | 32 | 7.26 | 3.17–16.64 | <0.001 | 4.61 | 2.36–9.03 | <0.001 |
| log2 HE4 | 109 | 37 | 43 | 2.70 | 1.98–3.68 | <0.001 | 2.98 | 1.99–4.45* | <0.001 |
| increase | |||||||||
| Multivariable models | |||||||||
| log2 HE4 | 2.23 | 1.60–3.10 | <0.001 | 3.31 | 2.10–5.21* | <0.001 | |||
| FIGO Stage (>I vs. I) | 5.77 | 2.62–12.7 | <0.001 | 3.73 | 1.80–7.75 | 0.001 | |||
| Age (years) | 1.64 | 1.00–2.67 | 0.048 | ||||||
*
Due to the non-linear relationship between log2 HE4 and PFS, the reported Hazard Ratio (HR) is for a 2 fold increase in the linear portion of the curve, namely HE4 from 64 to 128 pmol/L.
Bold numbers indicate a statistically significant difference with a p < 0.05.
$
log-rank test p-value.