Table 1.

TRPs expression in cancer and correlation with patient survival prognosis.

Channel	Cancer Type	Expression			Prognosis	References
		Healthy/Benign	Tumor	Invasive
TRPC1	Breast basal/lymph nodes Breast ductal adenocarcinoma	Yes yes	↑ ↑	↑	poor	Azimi et al., 2017; Dhennin-duthille et al., 2011
TRPC5	Colon	yes	↑	↑	poor	Chen et al., 2017a
TRPC6	Prostate	yes	↑	↑		Yue et al., 2009
	Glioblastoma	yes	↑	↑		Chigurupati et al., 2010
	Esophageal squamous cell carcinoma	yes	↑	↑	poor	Zhang et al., 2013
	Breast/Invasive ductal adenocarcinoma	yes	↑			Guilbert et al., 2008; Dhennin-duthille et al., 2011
TRPM2	Breast	yes	↑	↑	Depends on subtype	Sumoza-Toledo et al., 2016
TRPM4	Prostate	yes	↑			Ashida et al., 2004; Singh et al., 2006
	Cervical	yes	↑			Narayan et al., 2007
TRPM7	Breast	yes	↑	↑	poor	Middelbeek et al., 2012; Meng et al., 2013
	Invasive ductal adenocarcinoma/lymph nodes	yes	↑	↑		Dhennin-duthille et al., 2011; Guilbert et al., 2013
	Pancreatic ductal adenocarcinoma/lymph nodes	yes	↑	↑	poor	Rybarczyk et al., 2012; Yee et al., 2015
	Nasopharyngeal	no	↑	↑	poor	Chen et al., 2015
	Ovarian; Prostate; Melanoma; Sarcoma			↑		Meng et al., 2013
TRPM8	Breast ductal adenocarcinoma	yes	↑	↑		Dhennin-duthille et al., 2011
	Prostate	yes	↑	loss		Tsavaler et al., 2001; Fuessel et al., 2003; Bidaux et al., 2005
	Urothelial carcinoma of bladder	yes	↑	↑	poor	Xiao et al., 2014
	Lung	Very low level	↑			Tsavaler et al., 2001
	Colon	no	↑			Tsavaler et al., 2001
	Melanoma	no	↑			Tsavaler et al., 2001
	Osteosarcoma	yes	↑	↑	poor	Zhao and Xu, 2016
TRPV2	Prostate	no		↑		Monet et al., 2010
	Bladder	yes (full isoform) (short isoform)	↑ ↓	↑ Loss		Caprodossi et al., 2008
	Esophageal squamous cell carcinoma	yes	↑	↑	poor	Zhou et al., 2014
	Gastric	yes	↑	↑	poor	Zoppoli et al., 2019
	Breast (Triple negative/basal subtype)	yes	↑		better	Elbaz et al., 2018
TRPV4	Breast	yes	↑	↑	poor	Lee et al., 2016; Lee et al., 2017
	Gastric		↑		poor	Lee et al., 2016
	Ovarian		↑		poor	Lee et al., 2016
	Glioma	yes	↑	↑	poor	Ou-yang et al., 2018

↑: increment; ↓: reduction.