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The PET images were aligned with the mouse brain MRI template atlas. We selected the hippocampus and cortex as the VOIs and calculated their percentages of injected dose per gram (%ID/g). PET/MRI template atlas fusion images and graphs representing [18F]DPA714 signals in APP/PS1 vs. Wt mice 12–13 and 15–16 months of age. Black and gray arrows point to cortex and hippocampus, respectively (*p < 0.05, **p < 0.01, ***p < 0.001).
