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. 2020 Sep 29;14:569108. doi: 10.3389/fnsys.2020.569108

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Copyright © 2020 Mattera, Pagani and Baldassarre.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in connection weights and PSP before and after fear reinstatement. First row: simulated connection weights before and after fear reinstatement. Second row: simulated effect of a 30 ms presynaptic stimulation on the PSP of the plastic connections of the model (the presynaptic stimulation was adjusted to obtain a change of maximum 10 mV in the postsynaptic unit). Third row: real data from Vouimba and Maroun (2011) showing that, as in simulation, inputs from the mPFC to BA increase after reinstatement, while those from BA to the mPFC decrease, restoring the synaptic strength to conditioning levels. The other synapses shown here to be stable have never been reported in the literature to undergo LTP or LTD during fear reinstatement.