FIGURE 2.

Overexpression of p53 in TP53-mutant pancreatic cancer cells suppressed cancer progression in vitro and in vivo. PANC-1 and Patu-8988 cells were infected with control or over-expressing TP53 lentiviruses. (A) p53 expression was analyzed by western blotting. (B) The cell proliferation assay was performed at the indicated time points. (C) Representative micrographs of cell migration assays at 48 h (left) and quantification results (right). (D) Representative micrographs of cell invasion assays (left) and quantification results (right). Data in panels (B–D) are shown as the mean ± SEM of 3 independent experiments. (E) Representative images, volumes and weights of subcutaneous xenografts of Patu-8988 cells with overexpressing p53 or control. Data represent means ± SEM for 5 mice per group. **P < 0.01.