Table 1.
Preliminary list of criteria
| Criteria | Threshold value | |||
|---|---|---|---|---|
| Clinical characteristics and disease course | ||||
| Respiratory rate | ≥ 22/min | ≥ 25/min | ≥ 30/min | |
| Peripheral oxygen saturation | ≤ 90% | ≤ 92% | ≤ 94% | |
| Ability to talk without stopping for a breath | < 5 s | < 8 s | < 10 s | |
| Blood pressure | Systolic BP ≤ 100 mmHg | Systolic BP ≤ 90 mmHg | Systolic BP ≤ 90 mmHg and diastolic BP ≤ 60 mmHg | |
| Heart rate | ≥ 110 bpm | ≥ 120 bpm | ≥ 125 bpm | |
| Confusion or impaired consciousness | NA | |||
| Hypothermia | ≤ 35 °C | ≤ 36 °C | ||
| Hyperthermia | ≥ 39 °C | ≥ 40 °C | ≥ 41 °C | |
| Clinically significant worsening within the last 24 h | NA | |||
| Days from the onset of initial symptoms and admission between 7 and 10 days | – | – | – | – |
| Comorbidities | ||||
| Age | ≥ 65 years | ≥ 70 years | ≥ 75 years | ≥ 80 years |
| Body mass index | ≥ 30 kg/m2 | ≥ 35 kg/m2 | ≥ 40 kg/m2 | |
| Cognitive disorder | mild | moderate | severe | – |
| COPD | Any stage | Stage III/IV | – | – |
| Respiratory failure with continuous oxygen therapy | – | – | – | – |
| Asthma | Any stage | Controlled with systemic glucocorticoid therapy | Unstable | – |
| Chronic renal failure | Moderate (GFR < 60 ml/min) | Severe (DFG < 30 ml/min) | Terminal | Dialysis |
| Cirrhosis | Any stage | Stage Child B or C | Stage Child C | – |
| Chronic heart failure | Any stage | NYHA ≥ III | – | – |
| Arterial hypertension | – | – | – | – |
| Diabetes | – | – | – | – |
| Neuro-vascular disease | – | – | – | – |
| Coronary artery disease | – | – | – | – |
| Personal history of VTE | – | – | – | – |
| Neoplasia | History of cancer | Active cancer | Cancer receiving chemotherapy | – |
| Human immunodeficiency virus (HIV) | History of HIV | Uncontrolled HIV | – | – |
| Primary immunodeficiency | – | – | – | – |
| Pregnancy | Any term | 3rd Trimester | – | – |
| ACE inhibitor or ARB | – | – | – | – |
| Nonsteroidal anti-inflammatory drug | – | – | – | – |
| Systemic glucocorticoid therapy | Any dosage | Dosage > 10 mg/day | ||
| Immunosuppressive drug | – | – | – | – |
| Living conditions | ||||
| Inappropriate dwelling (homeless, frail relative at home, long-term care institution) | – | – | – | – |
| Lack of support person (family member or friend) | – | – | – | – |
| Home follow-up impossible (no general practitioner, telephone contact not possible, etc.) | – | – | – | – |
y years, VTE venous thrombo-embolism